Main prediction
Bills -6.5
- Published odds
- 1.72
- Odds source
- Author supplied · bookmaker not provided
Match information
- Competition
- NFL 2026 · Week 3
- Date
- 2026-09-27
- Kickoff
- 1:00 PM EDT
- Venue
- Highmark Stadium, Orchard Park, NY
- Records
- Chargers 0-2; Bills 2-0
Team news and projected personnel
Projected personnel, not confirmed lineups. Sunday and Monday final game designations were not available at the verified update time.
Los Angeles Chargers
Projected offense
- QB: Justin Herbert
- RB: Omarion Hampton
- WR: Ladd McConkey
Projected defense
- S: Derwin James (DNP)
Buffalo Bills
Projected offense
- QB: Josh Allen
- RB: James Cook
- TE: Dalton Kincaid
- WR: DJ Moore (limited)
Injuries and availability
Match analysis
Buffalo has opened its new stadium with a 2-0 record, a league-best 38.5 points per game and 427.5 yards per game. Josh Allen's five touchdown passes without an interception and James Cook's 5.7 yards per carry give the offense answers against both light and loaded boxes. The Chargers are 0-2, average only 14 points and carry a -4 turnover differential after Justin Herbert's three interceptions.
Los Angeles had a crowded DNP list Wednesday: Derwin James, Khalil Mack, Trey Pipkins, Elijah Molden, Kayode Awosika, Charlie Kolar, Brenen Thompson and Dalvin Tomlinson. Rashawn Slater, Cole Strange and Tuli Tuipulotu were limited. Buffalo listed Keon Coleman, Ed Oliver and T.J. Sanders as DNP, while DJ Moore and Jordan Hancock were limited. These were practice reports without Sunday game designations; the ZIP's OUT language for Pipkins was not retained.
The tactical burden falls on Herbert to keep Buffalo's pass rush from turning the contest into short fields. Omarion Hampton can slow the rush if Los Angeles stays on schedule, but chasing Allen removes that option and stresses a compromised protection group. Bills -6.5 requires a touchdown margin; Buffalo's +2 turnover differential against the Chargers' -4 and the health questions across Los Angeles' line and secondary support that demand, while late Herbert drives remain the back-door risk.
Sources
- NFL Week 3 scheduleFixture identity, date, kickoff and home/away · accessed September 24, 2026
- NFL Week 3 injury reportPractice participation and available game designations · accessed September 24, 2026
- NFL Game CenterRecords, team leaders, early-season statistics, venue and injuries · accessed September 24, 2026
Final prediction
Prediction: Bills -6.5
Published odds: 1.72